Abcam, ab167895, Recombinant Human LIMD2 protein

Size: 100µg
Recombinant Human LIMD2 protein is a Human Full Length protein, in the 1 to 127 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9BT23,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.4Constituents: PBS, 20% Glycerol (glycerin, glycerine)

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIMD2 also known as LIM domain-containing protein 2 acts as a molecular adapter involved in cellular processes. It has a mass of approximately 14 kDa and exhibits widespread expression in various tissues including tumor tissues. This protein contains a single LIM domain which functions in protein-protein interactions allowing it to interact with multiple binding partners.
Biological function summary
The protein plays a significant role in cellular adhesion and migration. LIMD2 directly influences the structure and dynamics of the cytoskeleton which are important for cellular movement. It can form part of multiprotein complexes where it interacts with cytoskeletal proteins and signaling molecules. LIMD2 modulates actin cytoskeleton and focal adhesion which are critical for cell motility and invasiveness.
Pathways
The protein is significantly involved in metastasis and integrin signaling pathways. LIMD2 interacts with integrin-linked kinase (ILK) impacting cell adhesion and spreading processes. It is also associated with the MAPK pathway where it may link to ERK influencing cell proliferation and differentiation. Through these interactions LIMD2 participates in complex signaling networks that regulate critical cellular functions.
LIMD2 has a strong connection with cancer metastasis and progression. Its expression correlates with tumor aggressiveness and poor prognosis in certain cancers including melanoma and bladder cancer. The protein connects with other cancer-related proteins such as integrin and ILK contributing to enhanced migratory and invasive characteristics of cancer cells. Targeting LIMD2 offers potential therapeutic strategies for limiting cancer metastasis.