Abcam, ab168680, Anti-FAT10 antibody

Size: 50µg
Mouse Polyclonal FAT10 Linkage-specific K63 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human UBD Linkage-specific K63.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human UBD Linkage-specific K63.O15205

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAT10 also known as UBD (Ubiquitin D) is a protein with an approximate mass of 18 kDa. It is a ubiquitin-like modifier involved in post-translational modifications. The protein is expressed in various tissues including the spleen thymus and lymph nodes with elevated levels often detected in cancer cells and tissues responding to proinflammatory cytokines. FAT10 plays a role in signaling for degradation of substrate proteins by the proteasome.
Biological function summary
FAT10 contributes to cellular processes like cell cycle regulation and apoptosis. It forms part of a complex with other ubiquitin-like proteins impacting protein degradation pathways. FAT10's interaction with the proteasome highlights its role in maintaining protein homeostasis and regulating immune response. By tagging proteins for degradation FAT10 influences cellular functions important for adaptation to stress and control of cell proliferation.
Pathways
FAT10 integrates into the NF-kB and TGF-beta pathways. This integration links it to inflammatory responses and tumorigenesis. In the NF-kB pathway FAT10 modulates protein degradation associated with inflammatory signaling and immune regulation. It has connections with other ubiquitin-related proteins such as ubiquitin itself to regulate activities within these pathways impacting cellular responses to external stimuli.
FAT10 shows a significant association with cancer and autoimmune diseases. Its overexpression is noted in various carcinomas including liver and colorectal cancers where it promotes oncogenic pathways and inhibits apoptosis. Additionally in autoimmune conditions such as lupus FAT10's role in regulating immune response becomes pertinent. It often interacts with proteins like p53 in cancer pathologies indicating its involvement in the stabilization and degradation of key regulatory molecules.