Abcam, ab168836, Anti-TCEB2/Elongin-B antibody

Size: 100µg
Rabbit Polyclonal TCEB2/Elongin-B antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ELOB aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ELOB aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q15370

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TCEB2 also known as Elongin-B is a protein that is part of the Elongin complex. It has an approximate molecular mass of 14 kDa. Elongin-B is widely expressed in various tissues including the heart liver and kidney. This protein works mechanically by increasing the transcription elongation efficiency of RNA polymerase II which is key for proper gene expression. Elongin-B functions within a cellular environment where it modulates transcriptional processes.
Biological function summary
Elongin-B participates as a component of the Elongin complex which also includes Elongin-C and Elongin-A. This complex enhances the rate of transcriptional elongation by alleviating the effects of transcriptional pausing or stalling. By facilitating the transcription of DNA to mRNA Elongin-B indirectly influences various cellular functions and growth processes. It acts by stabilizing other subunits of the complex contributing to the overall efficiency of gene expression systems.
Pathways
Elongin-B takes part in the ubiquitin-proteasome pathway a critical cellular system for protein degradation and turnover. It partners with others like Von Hippel-Lindau (VHL) protein within this pathway. Apart from protein degradation Elongin-B is also involved in the regulation of hypoxia-inducible factor (HIF) connecting it to pathways related to cellular response to oxygen levels. This interaction illustrates the protein's role in managing levels of various proteins related to stress responses in cells.
Elongin-B has implications in cancer and von Hippel-Lindau disease. Abnormal functioning or expression influences cellular mechanisms like uncontrolled cell growth seen in cancer proliferation. Elongin-B's interaction with VHL protein affects von Hippel-Lindau syndrome a condition that leads to tumor and cyst development in different parts of the body. The study of Elongin-B's role in these pathologies helps in understanding disease progression and identifying potential therapeutic targets.