Abcam, ab168928, Anti-CREB5 antibody

Size: 50µg
Mouse Polyclonal CREB5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CREB5.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CREB5.Q02930

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CREB5 also known as cAMP responsive element binding protein 5 is a transcription factor important for regulating gene expression. This protein has a mass of approximately 57 kDa and belongs to the CREB family of proteins. It is found expressed in various tissues including the brain lung and kidney. CREB5 binds to the cAMP response element (CRE) sequence found in the promoters of certain genes to modulate their transcription.
Biological function summary
CREB5 plays a role in the response to cellular stress and adaptation. It participates in mediating cellular responses through transcriptional activation influenced by signals such as hormones growth factors and neurotransmitters. CREB5 forms complexes with other transcription factors and coactivators enhancing or repressing the transcription of target genes depending on the context. It influences processes such as differentiation proliferation and survival of cells.
Pathways
CREB5 is involved in the cAMP signaling pathways and MAPK/ERK pathways. These pathways regulate various cellular functions including metabolism cell cycle progression and synaptic plasticity. CREB5 interacts with proteins like CREB1 and CREB3 which together contribute to the dysregulation of these pathways when mutations or malfunctions occur.
CREB5 has been associated with neurodegenerative disorders like Alzheimer's disease and certain types of cancer such as lung cancer. Variants in the expression or function of CREB5 can markedly affect the disease process often interacting with proteins like ATF4 in Alzheimer's which is implicated in stress responses and with NF-kB in cancer involved in immune response and cell survival mechanisms. Understanding CREB5's role provides insights into therapeutic targets for these conditions.