Abcam, ab169036, Anti-TRIM45 antibody

Size: 50µg
Mouse Polyclonal TRIM45 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TRIM45.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TRIM45.Q9H8W5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM45 also known as tripartite motif-containing protein 45 belongs to the TRIM/RBCC protein family. It acts mechanically as an E3 ubiquitin-protein ligase facilitating the attachment of ubiquitin to substrate proteins a process vital for proteasomal degradation. TRIM45 has an approximate mass of 55 kDa. Expression of TRIM45 occurs in various tissues particularly in the brain. It contains a RING finger domain one B-box type zinc finger and a coiled-coil region defining its structure.
Biological function summary
TRIM45 functions in the regulation of transcriptional activity and cell signaling pathways. It operates independently and may also form part of a larger protein complex during these activities. TRIM45 plays a role in cellular stress responses and modulates transcription factors through its ubiquitinligase activity thereby influencing gene expression. By controlling these processes TRIM45 impacts cellular proliferation and survival.
Pathways
TRIM45 participates in critical signaling pathways such as the MAPK/ERK pathway and the Wnt signaling pathway. In the MAPK/ERK pathway TRIM45 interacts with various kinases to regulate cell growth and differentiation. In the Wnt signaling pathway TRIM45 associates with proteins like β-catenin to influence cell fate decisions. These connections enable TRIM45 to coordinate cellular responses to environmental stimuli impacting many cellular processes.
TRIM45 has a connection to neurodegenerative diseases and certain cancers. Alterations in TRIM45 expression or function may contribute to the pathogenesis of diseases like glioblastoma. Decreased or dysfunctional TRIM45 can lead to dysregulated cell growth making TRIM45 a potential target for therapeutic intervention. Studies have shown interactions of TRIM45 with proteins involved in these conditions such as APC in cancer progression emphasizing its significance in pathological contexts.