Abcam, ab169136, Anti-GPR61 antibody

Size: 50µg
Mouse Polyclonal GPR61 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GPR61.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GPR61.Q9BZJ8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR61 also known as G protein-coupled receptor 61 belongs to the family of GPCRs. It has a molecular weight of roughly 44 kDa. This receptor expresses mainly in the central nervous system with higher concentration in brain regions such as the thalamus and hypothalamus. Like other GPCRs it likely interacts with heterotrimeric G proteins to transmit extracellular signals into the cell although specific ligands for GPR61 remain unidentified.
Biological function summary
GPR61 plays a role in neuronal signaling and possibly in modulating mood and cognition. It does not form known multi-protein complexes. However it interacts within signaling networks that influence neural pathways. Researchers consider GPR61 important in understanding neurochemical pathways that influence physiological processes although the exact mechanisms remain to be clearly defined.
Pathways
GPR61 activity affects key signal transduction routes in the brain. It interacts with the cAMP signaling pathway which impacts neurotransmitter release and neuronal development. GPR61 relates closely to other GPCRs like GPR62 and GPR63 in their contribution to brain signaling networks. This receptor also potentially influences metabolic pathways by modulating adipogenesis through yet undetermined partners in the adipose tissue.
Alterations in GPR61 function associate with conditions such as schizophrenia and obesity. In schizophrenia its dysregulation may disrupt normal brain signaling processes interacting indirectly with dopamine receptors that compound disease symptoms. Regarding obesity GPR61 is linked to metabolic dysregulation possibly through its influence on energy balance and fat storage associated with adiponectin signaling. Understanding these interactions remains critical for potential therapeutic targeting in these disorders.