Abcam, ab169461, Anti-Z-protein antibody

Size: 50µg
Mouse Polyclonal Z-protein antibody - Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TMBIM4.Q9HC24

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Z-protein also known as Protein Z or ZP plays an important role in various biological processes. It is a small protein with a mass of approximately 62 kilodaltons. Researchers have found Z-protein to be expressed prominently in the liver and to some extent in the pancreas. Its expression levels suggest an involvement in important metabolic and signaling functions specific to these organs.
Biological function summary
Z-protein contributes to the regulation of coagulation. It is part of the coagulation cascade forming complexes with other key proteins to control blood clot formation. This protein interacts with the Z-dependent protease inhibitor (ZPI) which is essential for the inhibition of factor X and factor XI in the coagulation process. Through these interactions Z-protein maintains the balance between coagulation and anticoagulation preventing excessive clotting and bleeding.
Pathways
Z-protein activity significantly influences the coagulation and fibrinolysis pathways. Within the coagulation pathway it plays a cooperative role with proteins such as thrombin and antithrombin which further modulates the activation of clotting factors. In the fibrinolysis pathway it helps regulate plasmin activity ensuring proper clot resolution. These interactions highlight the protein's centrality to maintaining hemostatic balance.
Malfunction or deficiencies in Z-protein have been linked to an increased risk of thrombosis and cardiovascular disease. Its inadequate function may elevate the likelihood of abnormal clot formation particularly because of its relationship with the coagulation factors and Z-dependent protease inhibitor. Additionally research has shown connections between Z-protein deficiencies and liver diseases suggesting its involvement with the pathways impacting liver function and health.