Abcam, ab169469, Anti-OVOL2 antibody

Size: 50µg
Mouse Polyclonal OVOL2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human OVOL2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human OVOL2.Q9BRP0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OVOL2 also known as Ovo-like zinc finger 2 is a transcription factor with a molecular weight of approximately 32 kDa. It plays a mechanical role in regulating gene expression by binding to specific DNA sequences. OVOL2 is expressed in various tissues most notably in the skin and hair follicles as well as epithelial tissues. Its function is connected to development processes such as differentiation and proliferation.
Biological function summary
OVOL2 influences epithelial-mesenchymal transition (EMT) which is important for embryogenesis and wound healing. It often interacts with other factors to stabilize epithelial cell identity. OVOL2 does not function alone; it forms a part of a network of transcription factors allowing it to modulate a wide range of downstream effects. This integrated action reflects its importance in maintaining the balance between cell states for example during development.
Pathways
The protein is essential in the Wnt signaling pathway and the TGF-beta pathway. These pathways play an integral role in controlling cell growth differentiation and migration. OVOL2 interacts with other proteins like beta-catenin and Smad proteins within these pathways. This interaction ensures precise control over cellular behavior and responses thereby influencing actively the development and progression of cells.
OVOL2 is relevant to cancer development particularly in breast and prostate cancers. The protein's activity can influence tumor progression due to its role in EMT and regulation of cell proliferation. It is connected to other proteins such as E-cadherin and Snail which are involved in cancer progression. Dysregulation of OVOL2 can lead to aberrant cell behavior and contribute to the oncogenic process.