Abcam, ab169623, Anti-CARD9 antibody

Size: 50µg
Mouse Polyclonal CARD9 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CARD9.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CARD9.Q9H257

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CARD9 also known as Caspase Recruitment Domain Family Member 9 is a signaling protein that plays a critical role in immune cell function. It has a molecular mass of approximately 59 kDa. CARD9 is primarily expressed in myeloid cells including dendritic cells monocytes and macrophages. Its mechanical function involves acting as an adaptor protein in immune signaling pathways allowing it to mediate the interaction between upstream pattern recognition receptors and downstream kinases.
Biological function summary
CARD9 is instrumental in the activation of the immune system’s response to pathogens such as fungi and bacteria. It functions as part of the CARD-Bcl10-MALT1 signaling complex which triggers the activation of NF-kB a transcription factor essential for inflammatory responses. Through its role in this complex CARD9 ensures the regulation of cytokine production which is fundamental for effective immune responses. CARD9's activity supports the defense against pathogenic infections by facilitating communication in immune signaling.
Pathways
CARD9 is involved in critical immune response pathways including the C-type lectin receptor (CLR) pathway. This pathway is essential in recognizing fungal pathogens and initiating immune responses. CARD9 interacts with proteins like Syk and Bcl10 in the CLR pathway to propagate immune signaling. CARD9's role in these pathways highlights its significance in regulating immune activities and maintaining homeostasis through signaling cascades.
CARD9 deficiency can result in impaired immune responses leading to increased susceptibility to fungal infections such as candidiasis. The protein plays an important role in maintaining appropriate immune functions to prevent such conditions. Furthermore dysfunction in CARD9 signaling has been associated with inflammatory bowel diseases. In this context CARD9 interacts with other immune proteins like NOD2 to modulate intestinal inflammation. Understanding CARD9’s role helps in elucidating its potential as a therapeutic target for managing these diseases.