Abcam, ab169769, Anti-PTP alpha (phospho Y798) antibody [EPR10369]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PTP alpha phospho Y798 antibody. Suitable for WB and reacts with Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10369,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protein Tyrosine Phosphatase Alpha (PTP alpha) also known as PTPRA serves as an enzyme that removes phosphate groups from specific tyrosine residues on proteins. It has an approximate molecular weight of 130 kDa. PTP alpha is located in the cell membrane and shows expression in various tissues including the brain liver and skeletal muscle. It functions as a signaling molecule that modifies the activity of several proteins playing a significant role in cell growth differentiation and mitosis.
Biological function summary
PTPRA influences cellular processes by serving as a regulator of the Src family of tyrosine kinases which are important for intracellular signal transduction. PTP alpha does not form part of a complex but rather exists as a monomer although it can interact with other proteins. Its activity helps maintain the balance of phosphorylation and dephosphorylation which is essential for cellular signaling homeostasis.
Pathways
PTP alpha acts in the integrin and growth factor receptor signaling pathways. It plays a role in integrin signaling by dephosphorylating substrates that modulate cell adhesion and migration. Additionally in growth factor receptor signaling PTP alpha modulates cell proliferation by interacting with substrates such as the epidermal growth factor receptor (EGFR). It shares pathway links with proteins like SRC and FAK emphasizing its regulatory role over them.
PTP alpha has associations with cancer particularly in cases such as colorectal and breast cancer. It affects cancer progression by modifying signaling involved in uncontrolled cell growth. Furthermore PTPRA has findings connecting it with neurodegenerative diseases like Alzheimer's through its effect on signaling cascades that involve amyloid precursor protein (APP). In these contexts PTP alpha’s interactions with proteins such as EGFR and FAK reveal its significance in disease pathology.