Abcam, ab170106, Anti-Cytokeratin 2e antibody [EPR10911]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal K22E antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10911,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cytokeratin 2e also known as keratin 2 or KRT2 is a type of intermediate filament protein with a mass of approximately 65 kDa. It functions mechanically to form and maintain structural integrity in epithelial cells. Cytokeratin 2e forms part of the keratin cytoskeleton which gives cells shape support and resilience against mechanical stress. This protein is expressed mainly in the upper spinous layer of the epidermis where it contributes to the specialized cytokeratin network.
Biological function summary
Cytokeratin 2e participates in cell differentiation and maturation within the epidermis. It does not operate in isolation but is integrated into a complex network of filaments comprising various keratin isoforms. This structured network assists in the development of the skin barrier which is essential for protecting the body from environmental damage. By facilitating the cohesion between keratinocytes Cytokeratin 2e plays a role in maintaining proper epidermal function.
Pathways
Cytokeratin 2e involves the epidermal differentiation pathway. It interacts primarily with other keratin proteins like keratin 1 (KRT1) to enhance the formation of a robust keratinocyte cytoskeleton. This association ensures proper skin cell function and epidermis homeostasis. The protein is also involved in the cornification pathway helping the process whereby keratinocytes become corneocytes the cells that make up the skin's outermost layer.
Cytokeratin 2e has links to ichthyosis bullosa of Siemens a keratinization disorder. Mutations affecting Cytokeratin 2e disrupt the structural stability of keratin filaments leading to skin fragility and blistering. Additionally its aberrant expression has associations with psoriasis where it may interact with immune-modulatory proteins like interleukin-17 (IL-17) aggravating the inflammatory environment. Understanding these connections helps in exploring therapeutic targets for managing these skin conditions.