Abcam, ab171082, Anti-TRA2B/SFRS10 antibody [EPR11831]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TRA2B/SFRS10 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11831,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: BSA, Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRA2B also known as SFRS10 is an RNA-binding protein involved in pre-mRNA splicing. This protein is part of the serine/arginine-rich family of splicing factors and is approximately 35 kDa in mass. TRA2B is expressed in various tissues with prominent expression in the brain testes and embryonic tissues. It plays a mechanical role by influencing splice site selection during the process of RNA splicing affecting the diversity of transcripts produced.
Biological function summary
TRA2B is important in the regulation of alternative splicing a process that impacts gene expression by allowing multiple protein isoforms from the same gene. TRA2B interacts with other components of the spliceosome complex such as the SR family of proteins to modulate splicing. It ensures the correct assembly of the spliceosome on pre-mRNA contributing to the generation of variant mRNA transcripts which is key for cellular differentiation and adaptation.
Pathways
TRA2B plays a significant role in the alternative splicing pathway impacting the cellular transcriptome. It is particularly linked with the mRNA processing pathway interacting with proteins such as TRA2A and ASF/SF2. These interactions facilitate the splicing of specific mRNA precursors coordinating their processing and translation which can impact key cellular processes like cell cycle regulation and apoptosis.
TRA2B has been associated with cancer and neurodegenerative diseases. Abnormal splicing events involving TRA2B can lead to misregulation of genes critical for cell proliferation therefore contributing to oncogenesis. In neurodegenerative conditions TRA2B-related splicing alterations impact neuronal gene expression. For instance disruption in TRA2B activity may influence the expression of tau proteins linking it to Alzheimer's disease pathology.