Abcam, ab171940, Anti-GRASP1 antibody [EPR11703]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GRASP1 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11703,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GRASP1 also known as GRIP1-associated protein 1 is a scaffold protein involved in trafficking in neurons. It is part of the GRIP (Glutamate Receptor Interacting Protein) family and has a molecular weight of about 90 kDa. GRASP1 is expressed in the brain especially in areas such as the hippocampus and cortex. Its function includes facilitating the transport and stability of proteins at synaptic sites playing a role in synaptic plasticity and signaling.
Biological function summary
GRASP1 interacts with other proteins to modulate the assembly and function of the AMPA receptor complex at synapses. It is important for proper neuronal signaling and communication as it organizes the cellular machinery required for synaptic strength. GRASP1 works as part of the AMPA receptor complex affecting neurotransmitter regulation and synaptic transmission efficiency. This protein's role in regulating synaptic receptor composition influences learning and memory processes in the brain.
Pathways
GRASP1 integrates into the glutamatergic signaling pathway impacting neural communication and plasticity. It is associated with regulating the trafficking pathways of AMPA receptors important for excitatory neurotransmission. GRASP1 interacts with proteins like GRIP1 and PICK1 which help in maintaining the receptor composition at synaptic junctions. These interactions sustain the dynamic modulation of synaptic strength an essential component of the nervous system's flexibility.
GRASP1 connects to neurodegenerative disorders like Alzheimer's disease. Changes in its function can contribute to synaptic dysfunction observed in such conditions. GRASP1 has been linked to proteins involved in neurotransmitter regulation and its dysregulation may influence the pathology of synaptic failure. In addition altered expression or function of GRASP1 has been associated with certain cognitive disorders further implicating its significance in maintaining synaptic health.