Abcam, ab171968, Anti-CACNA1F antibody [EPR11822]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CACNA1F antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11822,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CACNA1F gene encodes the alpha-1F subunit of a voltage-dependent L-type calcium channel. This protein also known as Cav1.4 has a mass of approximately 230 kDa. It facilitates the influx of calcium ions into the cells in response to changes in electric potential across the cell membrane. The protein is expressed mainly in the retina where it plays an important role in the function of photoreceptor cells.
Biological function summary
The CACNA1F protein influences neurotransmitter release by regulating calcium entry which is essential for visual processing. It functions as a part of a larger voltage-gated calcium channel complex where its role is to fine-tune calcium signals. This precise control is necessary for the proper response to light stimuli in the eye allowing effective signal transmission to the visual pathways.
Pathways
The CACNA1F protein integrates into the calcium signaling pathway important for neuronal communication and sensory processes. It is also linked to the phototransduction cascade in the retina. Within these pathways CACNA1F interacts with related proteins like beta subunits that modulate the activity of the L-type calcium channels impacting overall visual function.
Mutations in the CACNA1F gene are associated with X-linked congenital stationary night blindness and other retinal disorders. These conditions can lead to an impaired vision due to the disrupted calcium flow in photoreceptors. Additionally CACNA1F shows a relationship with other calcium channel proteins like CACNA1S potentially influencing disorder phenotypes through altered ionic homeostasis.