Abcam, ab171984, Anti-ITPKB antibody

Size: 50µg
Mouse Polyclonal ITPKB antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Inositol-trisphosphate 3-kinase B.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Inositol-trisphosphate 3-kinase B.P27987

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The biological target Inositol-trisphosphate 3-kinase B (ITPKB) plays an important role mechanically in cellular signaling by phosphorylating inositol 145-trisphosphate (IP3) to produce inositol 1345-tetrakisphosphate (IP4). Also known as ITPK-B or IP3 3-kinase B it is a 66-kDa protein expressed mainly in the brain hematopoietic cells and the immune system. This enzyme's activity regulates intracellular calcium levels thereby influencing various cellular processes.
Biological function summary
ITPKB modulates immune system processes and neural function. It does not form part of a larger protein complex but interacts with other molecules to influence cellular activities. Regulation of calcium signaling through the activity of ITPKB affects T-cell development and function as well as neurogenesis in the brain. By altering IP3 and IP4 levels ITPKB has an impact on the pathways that modulate cell proliferation and differentiation.
Pathways
ITPKB is integral to calcium signaling and the phosphoinositide pathway. In the calcium signaling pathway it controls the production of IP4 which in turn regulates calcium homeostasis and related downstream effects. In the phosphoinositide pathway ITPKB works together with related proteins like IP3 receptors and phospholipase C to affect signal transduction. These pathways are important for immune response and neural development.
ITPKB is linked to immune deficiency and neurological conditions. Dysregulation of this protein can lead to autoimmune diseases due to its role in T-cell regulation. Connections also exist between ITPKB and proteins like calcineurin where imbalance can contribute to neurological disorders such as schizophrenia. Restoration of ITPKB function offers potential therapeutic approaches for managing these diseases.