Abcam, ab172194, Recombinant Human Tau441 protein

Size: 20µg / 50µg
Recombinant Human Tau441 protein is a Human Fragment protein, in the 50 to 421 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, WB.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P10636,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris-HCl buffer, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tau441 also known as microtubule-associated protein tau (MAPT) plays an important role in stabilizing microtubules within neuronal cells. This protein has a molecular weight of approximately 50 kilodaltons. Tau441 is most highly expressed in neurons of the central nervous system. It assists in maintaining neuronal structure and due to its microtubule-binding domains contributes to proper axonal transport. The proper function of Tau441 is essential for neuronal health and function.
Biological function summary
Tau441 is an important component in the assembly and stability of microtubule structures. It associates with other tau isoforms to form a microtubule lattice complex important for neuron polarization and intracellular transport. Tau441 influences cell signaling and synaptic function by regulating microtubule dynamics. It also interacts with motor proteins to facilitate the transport of organelles playing a significant role in maintaining neuron structure and functionality under physiological conditions.
Pathways
Tau441 is involved in the MAP kinase signaling pathway and the regulation of cytoskeleton organization. It interacts with proteins like kinases that phosphorylate tau affecting its microtubule-binding capability highlighting its role in intracellular transport processes. Tau441 modulates the structure and dynamics of microtubules enabling effective transmission of cellular signals and materials throughout the neuron which is vital in maintaining neuronal integrity and function.
Tau441 is notably associated with Alzheimer's disease and frontotemporal dementia. Abnormal phosphorylation of Tau441 results in the formation of neurofibrillary tangles a hallmark of Alzheimer's disease. The dysregulated interaction between Tau441 and kinases like glycogen synthase kinase-3β (GSK-3β) leads to tau hyperphosphorylation contributing to neuronal degeneration. These pathological changes in Tau441 are linked to the onset and progression of neurodegenerative diseases emphasizing the importance of studying and targeting Tau441 in clinical research and therapeutics.