Abcam, ab172475, Anti-Aspartate beta hydroxylase antibody [EPR10351]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Aspartate beta hydroxylase antibody. Suitable for IHC-P, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10351,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Aspartate beta hydroxylase (ABH) also known as aspartyl/asparaginyl beta-hydroxylase is an enzyme that catalyzes the post-translational hydroxylation of aspartyl and asparaginyl residues in proteins. It has an estimated molecular mass of 86 kDa. Aspartate beta hydroxylase exhibits expression in a variety of tissues including the liver brain and heart. Its expression can change in response to pathological states indicating a role in physiological and disease processes.
Biological function summary
Aspartate beta hydroxylase has a significant role in cellular functions by contributing to the modification and regulation of proteins involved in cellular adhesion migration and signaling. Although it functions individually ABH also interacts with other molecular components within the cell influencing a range of cellular processes such as differentiation and proliferation. These modifications affect the protein interactions and stability playing an essential role in cellular homeostasis and development.
Pathways
Aspartate beta hydroxylase contributes to important signaling pathways and cellular mechanisms such as the Notch signaling pathway. In this context it participates in essential cellular communications affecting cell fate determination processes. Other related proteins in these pathways involve Notch receptors and ligands which undergo modifications by ABH activity facilitating accurate signal transduction and cellular response.
The dysregulation of aspartate beta hydroxylase is associated with several conditions most notably cancer and congenital heart defects. In cancer overexpression of ABH can lead to enhanced tumor progression and metastasis. This condition correlates with proteins involved in cellular growth and migration such as integrins. In congenital heart defects abnormal levels of ABH may influence heart tissue development and integrity linked with Notch receptors that are important for cardiac morphogenesis.