Abcam, ab172542, Anti-NR2E3/RNR antibody

Size: 50µg
Mouse Polyclonal NR2E3/RNR antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NR2E3.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human NR2E3.Q9Y5X4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NR2E3/RNR protein also known as nuclear receptor subfamily 2 group E member 3 plays an important role in gene regulation particularly in retinal cells. Its molecular weight is approximately 45 kDa. This nuclear receptor expresses in specific tissues especially within the retina where it influences photoreceptor health and development. Its expression primarily affects rods and cones impacting the overall visual function.
Biological function summary
NR2E3/RNR functions as a transcription factor fine-tuning the expression of genes vital for photoreceptor cells. It forms part of a complex with other transcription factors including NRL and CRX which coordinate to regulate cell differentiation and response to light. This protein significantly influences the switch between rod and cone photoreceptor cell fates impacting the balance and functionality of these critical cells in the retina.
Pathways
NR2E3/RNR participates in the phototransduction and visual cycle pathways. These pathways account for the conversion of light signals into neural signals facilitating vision. In the phototransduction pathway NR2E3/RNR is related to proteins such as rhodopsin and transducin playing a role in modulating photoreceptor roles. Through these pathways it contributes to maintaining retinal integrity and proper light response.
Mutations in NR2E3 correlate with certain retinal degenerative diseases such as Enhanced S-Cone Syndrome (ESCS) and retinitis pigmentosa. These diseases often link to its interactions with proteins like CRX which also play roles in retinal health. Disruptions in NR2E3/RNR function can lead to photoreceptor cell dysfunction and degeneration highlighting its importance in retinal disease mechanisms and offering potential therapeutic targets.