Abcam, ab172961, Anti-FBXL19 antibody [EPR11957]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FBXL19 antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11957,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBXL19 also known as F-box and leucine-rich repeat protein 19 functions as a subunit of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. This complex plays a vital role in targeting cellular proteins for ubiquitination and proteasomal degradation. The molecular mass of FBXL19 is approximately 74 kDa. FBXL19 can be found in several tissues with notable expression in the brain and reproductive organs. It also locates within the nucleus of cells where it interacts with other components of the ubiquitination machinery.
Biological function summary
FBXL19 influences the regulation of protein stability and turnover through its participation in the SCF complex. This complex involving SKP1 CUL1 and other F-box proteins mediates ubiquitination by recognizing specific phosphorylated substrates. FBXL19 facilitates the recognition of these substrates impacting cellular processes such as cell cycle progression signal transduction and transcription regulation. The precise action of FBXL19 within these complexes highlights its role in maintaining cellular homeostasis by ensuring timely protein degradation.
Pathways
FBXL19 is integral to the protein degradation pathway and the regulation of the cell cycle. The protein interacts with the ubiquitin-proteasome system to modulate the levels of cell cycle regulators maintaining proper cellular division and function. FBXL19 also shows interconnection with proteins such as SKP2 in the regulatory pathway of cell cycle highlighting its involvement in pathways controlling cell proliferation and differentiation.
FBXL19 has links to cancer and neurodegenerative diseases. Its role in ubiquitin-mediated proteolysis affects tumor suppressor proteins and oncogenes which can contribute to oncogenesis. Dysregulation of FBXL19 activity may also impact proteins associated with neurodegenerative disorders such as tau or amyloid precursor protein suggesting a potential involvement in pathologies like Alzheimer's disease. The connection between FBXL19 these proteins and related pathways emphasizes its importance in understanding molecular mechanisms of disease progression.