Abcam, ab173416, Anti-URP2/Kindlin-3 antibody [3D6]

Size: 100µg
Mouse Monoclonal URP2/Kindlin-3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:3D6,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Epitope:The epitope for clone 3D6 has been mapped to residues 181-461.

Product details:
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This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
URP2 also known as Kindlin-3 is a protein involved in integrin signaling and cell adhesion processes. It plays a critical role in facilitating the linkage between integrins and the actin cytoskeleton enhancing the signaling cascades that promote cellular adhesion and motility. Kindlin-3 has a molecular mass of approximately 75 kDa. This protein is ubiquitously expressed but found in particularly high levels in hematopoietic cells including leukocytes and platelets.
Biological function summary
Kindlin-3 is essential for the activation and stabilization of integrin complexes which are important for the processes of cell migration adhesion and immune response. It works as a part of the integrin adhesion complex interacting with other cytoplasmic proteins to ensure proper integrin function. Disturbance in Kindlin-3's activity can lead to impaired cell adhesion and migration underlining its importance in both normal cellular functions and pathological conditions.
Pathways
Kindlin-3 plays a significant role in the integrin and focal adhesion signaling pathways. Its interactions within these pathways link it closely with proteins like talin and vinculin which coordinate the signaling transmissions required for cellular movement and environmental interaction. Kindlin-3's ability to regulate integrin activity allows it to participate in cellular processes important for tissue repair and immune responses.
Deficiencies or mutations in Kindlin-3 have strong associations with conditions such as Leukocyte Adhesion Deficiency III (LAD-III) and Glanzmann thrombasthenia-like bleeding disorder. These conditions arise from the impaired integrin activation affecting leukocyte recruitment and platelet aggregation. The protein's role in these disorders highlights its connection with proteins like integrins which fail to function properly in the absence of normal Kindlin-3 activity leading to clinical manifestations in affected individuals.