Abcam, ab174296, Anti-Ube2G2 antibody [EPR9248(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Ube2G2 antibody. Suitable for IP, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9248(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ube2G2 also known as Ubiquitin-conjugating enzyme E2 G2 is involved in the ubiquitin-proteasome pathway. This enzyme functions by facilitating the transfer of ubiquitin from E1 activating enzymes to target proteins marking them for degradation. It has a molecular mass of approximately 21 kDa and is expressed in various tissues with noticeable presence in the heart and skeletal muscle. The activity of Ube2G2 is essential for maintaining protein homeostasis in cells.
Biological function summary
Ube2G2 interacts as a part of the ubiquitin-conjugating system forming complexes with E3 ligases like gp78. These complexes determine substrate specificity and enhance the degradation of misfolded or damaged proteins. The function of Ube2G2 in protein degradation is important for cellular processes including cell cycle regulation and stress responses. The enzyme therefore contributes to maintaining cellular integrity by preventing the accumulation of nonfunctional proteins.
Pathways
Ube2G2 plays an integral role in the endoplasmic reticulum-associated degradation (ERAD) pathway which orchestrates the removal of defective proteins from the endoplasmic reticulum. Ube2G2 collaborates with the E3 ligase gp78 and these together facilitate the ubiquitination and subsequent proteasomal degradation of target substrates. Additionally Ube2G2 influences calcium-related signaling pathways impacting cellular calcium homeostasis.
Ube2G2's dysfunction is linked with neurological disorders and cancer. Impairments in Ube2G2 activity may lead to defective ERAD contributing to neurodegenerative disorders through the accumulation of toxic protein aggregates. In cancer altered Ube2G2 expression affects the degradation of oncogenic proteins implicating it in tumorigenesis. In these contexts its interaction with proteins like gp78 becomes significant in understanding how cellular degradation pathways are disrupted.