Abcam, ab174436, Anti-DLX-3 antibody [Anti-Dlx3b]

Size: 100µg
Mouse Monoclonal DLX-3 antibody. Suitable for IHC - Wmt and reacts with Zebrafish samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:Anti-Dlx3b,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Zebrafish,
Applications:IHC - WmtSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purity-undefined SDS-PAGE, Purification notes-ab174436 is produced in vitro using hybridomas grown in serum-free medium, and then concentrated by chemical fractionation. Near homogeneity as judged by SDS-PAGE., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: 99% HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DLX-3 also known as Distal-less homeobox 3 is a transcription factor with a molecular weight of approximately 32 kDa. It is a member of the homeobox gene family which plays roles in developmental processes. DLX-3 is mainly expressed in tissues like skin hair follicles and the placenta. It functions by binding to specific DNA sequences causing changes in gene expression during development.
Biological function summary
DLX-3 affects the development and differentiation processes in organisms. It interacts within a complex network of other homeobox genes influencing the development of craniofacial structures and skin. During early stages its role includes promoting cell differentiation necessary for forming specific tissues particularly in the ectoderm layer derivatives such as skin.
Pathways
Several genes contribute to the pathways involving DLX-3. DLX-3 participates in the Wnt signaling and BMP pathways acting as a regulator of gene transcription necessary for cellular differentiation. It interacts with other proteins like BMP2 showing functional overlap with other members of the DLX gene family. Through these interactions DLX-3 helps coordinate proper tissue development and maintenance.
DLX-3 has associations with ectodermal dysplasias and certain craniofacial anomalies. It links to disorders like Tricho–Dento–Osseous (TDO) syndrome where mutations lead to defects in hair teeth and bone development. Apart from these DLX-3’s interactions with MSX1 highlight its role in dental and cranial disorders contributing to further understanding of hereditary conditions affecting developmental processes.