Abcam, ab174438, Anti-ATP5D antibody [4D11]

Size: 100µg
Mouse Monoclonal ATP5D antibody. Suitable for WB and reacts with Mouse, Rat, Cow samples. Cited in 2 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4D11,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Cow,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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Properties and Storage Information:
Form-Liquid, Purification notes-ab174438 is produced in vitro using hybridomas grown in serum-free medium, and then concentrated by chemical fractionation. Near homogeneity as judged by SDS-PAGE., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: 99.9% HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATP5D also known as ATP synthase subunit delta is a part of the mitochondrial ATP synthase complex. This protein plays a role in the conversion of ADP to ATP by facilitating proton flow across mitochondrial membranes. ATP5D has a molecular mass of approximately 18-20 kDa. Expression of ATP5D occurs in tissues with high energy demands such as the heart skeletal muscle and liver reflecting its role in energy metabolism.
Biological function summary
ATP5D contributes to the production of cellular energy by acting as an essential subunit in the F1 region of the F1Fo ATP synthase complex. This complex is responsible for ATP synthesis during oxidative phosphorylation. ATP5D's role is critical for maintaining the structural integrity and function of the ATP synthase complex. Its presence ensures efficient ATP production essential for various cellular processes.
Pathways
ATP5D functions within oxidative phosphorylation and energy metabolism pathways. It is closely associated with other ATP synthase subunits required for the ATP production process. Complex interactions include interactions with proteins such as ATP5A and ATP5B within the ATP synthase complex which work together in the energy production pathway essential for cell survival.
Defects or mutations in ATP5D can be related to mitochondrial diseases like mitochondrial encephalomyopathy. Alterations in its normal function can lead to improper cellular energy production. Additionally ATP5D mutations may impact disorders like Leigh syndrome where mitochondrial dysfunction plays a critical role. Understanding ATP5D's connections including those with proteins involved in these disorders helps unravel its impact on these conditions.