Abcam, ab174603, Anti-Mouse MHC Class I H 2Dd antibody [34-1-2S] - Low endotoxin, Azide free

Size: 100µg
Mouse Monoclonal HA13 antibody. Carrier free. Suitable for Flow Cyt, FuncS and reacts with Mouse samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:34-1-2S,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:Yes,
Reacts with:Mouse,
Applications:FuncS, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab174603 reacts with the mouse MHC class I, H-2Kd and H-2Dd. This cytotoxic antibody also cross-reacts with Kb, s, r, q, p.

Product details:
Endotoxin: Less than 0.001 ng/ug antibody, as determined by the LAL assay.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.2, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Mouse MHC Class I H-2Dd also known as H-2Dd or simply 2Dd is a major histocompatibility complex (MHC) protein. It has a critical role in the immune system by presenting peptide antigens to CD8+ T cells. The protein has a mass of approximately 45 kilodaltons. H-2Dd is mainly expressed on the surface of nearly all nucleated cells in mice serving as an important component in immune recognition.
Biological function summary
The H-2Dd protein forms a complex with beta-2 microglobulin to create the MHC class I molecule. This complex plays an essential role in the identification and elimination of infected or transformed cells by the immune system. Specifically it binds to small peptide fragments derived from cytosolic proteins and displays them on the cell surface for surveillance by cytotoxic T lymphocytes.
Pathways
H-2Dd is involved in antigen processing and presentation pathways. It operates within the context of the adaptive immune response a pathway where it interacts with transporter associated with antigen processing (TAP). Another important pathway is the proteasome degradation pathway that generates peptide fragments presented by H-2Dd. The closely related MHC class I molecules like H-2Kk also participate in these processes ensuring proper immune system function.
H-2Dd's role ties prominently to autoimmune diseases and transplant rejection. Variations in this protein can influence susceptibility to autoimmune conditions such as rheumatoid arthritis by altering the peptide presentation to T cells. H-2Dd is also connected to graft-versus-host disease during transplantation procedures where its mismatch can trigger immune rejection. In such cases interactions with other proteins like H-2Dd related peptides exacerbate the immune response necessitating careful consideration in clinical settings.