Abcam, ab174629, Anti-ABCC9 antibody [N319A/14] - C-terminal

Size: 100µg
Mouse Monoclonal ABCC9 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Rat, Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Abcc9 aa 1500 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:N319A/14,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Rat, Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Abcc9 aa 1500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P70170,
Specificity:ab174629 does not crossreact with SUR2B.

Product details:
The clone number has been updated from S319A-14 to N319A/14, both clone numbers name the same antibody clone.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABCC9 also known as SUR2 (sulfonylurea receptor 2) is a protein part of the ATP-binding cassette transporter superfamily. It weighs approximately 174 kDa. The protein functions as a regulatory subunit of the KATP potassium channel controlling ion flow through cell membranes. ABCC9 is present in various tissues with significant expression in cardiac and skeletal muscles and in pancreatic cells.
Biological function summary
ABCC9 plays an important role in the response to metabolic changes by linking cellular excitability to metabolism. As a component of the KATP channel complex it regulates the channel's open and closing states in response to intracellular ATP levels. This regulation impacts muscle contraction and insulin release significant processes in energy maintenance and homeostasis.
Pathways
ABCC9 is integrated into significant signaling networks such as the insulin secretion pathway and the cardiac muscle contraction pathway. It interacts with proteins like Kir6.2 a potassium channel protein forming the pore of KATP channels. These pathways illustrate ABCC9's involvement in glucose homeostasis and cardiac rhythm regulation.
ABCC9 is linked to heart disorders such as dilated cardiomyopathy and metabolic conditions like hyperinsulinism. Mutations or dysregulation of ABCC9 affect its interaction with proteins like Kir6.2 influencing cardiac excitability and insulin secretion. The dysfunction of this protein could result in abnormal heart rhythms and impaired insulin regulation contributing to the mentioned diseases.