Abcam, ab174651, Anti-EDF1 antibody

Size: 100µg
Rabbit Polyclonal EDF1 antibody. Suitable for IP, WB, IHC-Fr and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human EDF1 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EDF1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O60869

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab174651 was affinity purified using an epitope specific to EDF1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EDF1 also known as endothelial differentiation-related factor 1 is a well-characterized protein of approximately 15 kDa. It is broadly expressed in various tissues with a notable presence in endothelial cells. The protein participates in the regulation of several cellular processes by modulating gene expression. EDF1 acts as a transcriptional coactivator in processes such as cellular differentiation and proliferation.
Biological function summary
EDF1 plays an important role in modulating transcriptional activity related to endothelial cell differentiation. It does not seem to form part of a larger complex instead directly influencing nuclear receptors to drive expression changes. In particular EDF1 interacts with the retinoid X receptor (RXR) to regulate the transcription of target genes involved in cellular response and growth.
Pathways
EDF1 significantly impacts the retinoic acid signaling pathway and the nitric oxide signaling pathway. These pathways are important for processes such as cell proliferation and vascular development. EDF1's interaction with RXR suggests potential connections with other proteins such as peroxisome proliferator-activated receptors (PPARs) which play roles in lipid metabolism and inflammation control.
EDF1 relates to cardiovascular diseases and certain cancers. Changes in EDF1 expression or function can influence endothelial cell behavior contributing to the development of atherosclerosis or tumor angiogenesis. Additionally there is an interplay between EDF1 and other proteins like VEGF in the context of these diseases affecting angiogenic processes and progression of vascular abnormalities.