Abcam, ab175365, Anti-P2Y13 antibody [2H1G9]

Size: 100µg
Mouse Monoclonal P2Y13 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human P2RY13 aa 1-50.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2H1G9,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human P2RY13 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9BPV8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from tissue culture supernatant., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
P2Y13 also known as P2RY13 is a G-protein coupled receptor part of the P2Y receptor family. It has a mass of approximately 42 kDa. Functionally P2Y13 recognizes extracellular nucleotides like ADP and initiates signaling cascades thereafter. This receptor is expressed in various tissues including the brain liver and immune cells. In the nervous system it plays a role in neurotransmission and might influence neuronal functions.
Biological function summary
P2Y13 participates in purinergic signaling. This pathway influences cellular responses and plays a role in multiple physiological processes. P2Y13 is not known to form part of a larger receptor complex but interacts with G-proteins to transmit signals within the cell. Its activity helps regulate lipid metabolism and influences energy homeostasis in the body.
Pathways
P2Y13 is involved in the ADP-mediated signaling pathway a critical component in the regulation of cholesterol and lipid metabolism. It interacts with proteins like G-protein subunits to activate downstream signaling pathways. In the broader context of these pathways P2Y13 supports cellular processes such as energy balance and detoxification of substances.
P2Y13 has been connected with cholesterol imbalance and related metabolic disorders. Its role in lipid homeostasis indicates it might be relevant in atherosclerosis a condition characterized by lipid accumulation in the arteries. P2Y13 also associates with neurological disorders due to its presence and role in neural tissues. It is connected to other purinergic receptors like P2Y12 in these disease contexts which collectively contribute to disease progression through dysregulated purinergic signaling.