Abcam, ab176057, Recombinant Human TRIAP1 protein

Size: 100µg
Recombinant Human TRIAP1 protein is a Human Full Length protein, in the 1 to 76 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O43715,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIAP1 also known as p53-regulated apoptosis-inducing protein 1 is a small protein with a mass of approximately 10 kDa. This protein is expressed in various tissues particularly those with high proliferative activity. TRIAP1 interacts with key components of cytochrome c release and helps to regulate the mitochondria's response to apoptotic signals. Its mechanical role is essential in cell survival and involves interactions with other proteins to stabilize the mitochondrial outer membrane.
Biological function summary
TRIAP1 is involved in maintaining mitochondrial function and promoting cell survival under stress conditions. It plays a significant role by forming a complex with other mitochondrial proteins such as PRELID1 which is involved in lipid transfer and homeostasis. This protein regulates the release of apoptogenic factors from mitochondria therefore controlling the intrinsic apoptosis pathway. Additionally TRIAP1's activity facilitates the stabilization of mitochondrial membranes against stress-induced depolarization.
Pathways
TRIAP1 plays an important role in the intrinsic apoptosis pathway where it prevents mitochondrial outer membrane permeabilization. It is closely related to the p53 signaling pathway as p53 regulates TRIAP1 expression levels in response to cellular stress. Through this pathway TRIAP1 collaborates with proteins like BCL-2 family members to maintain mitochondrial integrity and prevent apoptosis ensuring cellular homeostasis under stress conditions.
TRIAP1 has been implicated in cancer development where its overexpression correlates with resistance to apoptosis in tumor cells. Its interaction with p53 and BCL-2 family members influences tumor progression and treatment resistance making it relevant in certain cancers like breast and ovarian cancer. Furthermore TRIAP1's involvement in metabolic disorders is observed through its role in maintaining mitochondrial function which can affect conditions such as mitochondrial dysfunction syndromes. Understanding these connections may offer insights into targeted therapeutic interventions.