Abcam, ab176587, Anti-LRRFIP1 antibody

Size: 100µL
Rabbit Polyclonal LRRFIP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LRRFIP1 aa 750 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LRRFIP1 aa 750 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q32MZ4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab176587 was affinity purified using an epitope specific to LRRFIP1 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LRRFIP1 also known as Leucine-Rich Repeat Flightless-Interacting Protein 1 is an important protein involved in several cellular processes. It has an approximate molecular mass of 85 kDa and is expressed in various tissues including immune cells and certain tumor tissues. The protein consists of leucine-rich repeats that play a significant role in its function serving regions that form protein-protein interactions.
Biological function summary
LRRFIP1 participates in innate immune responses and acts as a transcriptional regulator. It is often found as part of a larger protein complex that influences key inflammatory pathways affecting the expression of genes linked to immune response. This protein can modulate signaling pathways influencing cell proliferation and differentiation linking it to the regulation of inflammation and immunity.
Pathways
The function of LRRFIP1 places it within the NF-kB signaling pathway and Wnt signaling pathway. In the NF-kB pathway LRRFIP1 acts by interacting with proteins that modulate gene transcription related to inflammatory responses. In the Wnt signaling pathway it associates with other proteins to regulate processes important for cell survival and development. The relationship with these pathways demonstrates LRRFIP1’s role in maintaining cellular homeostasis and orchestrating immune responses.
LRRFIP1 is connected to autoimmune diseases and certain cancers such as breast cancer. Its deregulation can lead to abnormal immune system activity or tumor progression. The protein engages with inflammatory cytokines and regulatory proteins like STAT3 which contributes to its involvement in these disorders. The study of LRRFIP1 will advance understanding in developing targeted therapies for conditions where it plays a critical role.