Abcam, ab176689, Anti-ZNF384 antibody

Size: 100µL
Rabbit Polyclonal ZNF384 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human ZNF384 aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF384 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8TF68

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF384 also known as zinc finger protein 384 acts as a transcription factor. It has a molecular mass of approximately 55 kDa. This protein contains multiple zinc finger motifs allowing it to bind to DNA. ZNF384 regulates the expression of various genes linked to cellular processes. It localizes to the nucleus where it performs its function. Although broadly expressed the protein shows higher expression in tissues such as the brain and bone marrow.
Biological function summary
This transcription factor plays a role in controlling gene expression networks essential to differentiation and development. ZNF384 contributes significantly to the regulation of genes involved in cell growth and proliferation. It is known to interact with the transcriptional complexes influencing downstream gene expression events that contribute to developmental processes. ZNF384's functionality is important in maintaining the balance of cellular proliferation and differentiation.
Pathways
ZNF384 finds integration within the MAPK signaling pathway and the Wnt signaling pathway. These pathways respond to extracellular signals and control various cellular processes like growth and differentiation. ZNF384 interacts with proteins such as CBP and p300 which are coactivators that modulate transcriptional activities. These interactions help integrate signals from different pathways influencing specific cellular responses.
Researchers associate ZNF384 with leukemia and osteosarcoma. In particular its fusion with transcriptional co-activators like EWS has implications in leukemogenesis often found in mixed-lineage leukemia (MLL). The presence of ZNF384 abnormalities may influence disease progression and patient prognosis. Understanding how ZNF384 interplays with related factors such as TET1 could provide insights into the pathogenesis of these disorders.