Abcam, ab178413, Anti-Syncollin antibody [EPR13149]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Syncollin antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13149,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.35% Sodium citrate, 0.17% Sodium chloride, 0.05% BSA, 0.03% EDTA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Syncollin also known as SYCN is a protein with a molecular mass of approximately 13 kDa. It is expressed mainly in the pancreatic acinar cells. Syncollin has critical involvement in the regulation of secretory pathways in the pancreas. Its primary role involves anchoring to the membranes of secretory granules which assists in the controlled release of digestive enzymes. Through its interaction with lipid environments Syncollin maintains stability and functionality of these granules ensuring efficient secretion processes.
Biological function summary
Syncollin contributes to the optimization of exocrine pancreatic functions. It acts within a complex that involves membrane-bound and cytosolic proteins which together facilitate the exocytosis of granules. Syncollin’s specific membrane-binding motif enhances its ability to anchor granules effectively increasing the precision of enzyme release. The protein's interaction with other cellular components supports the structural integrity of secretory vesicles impacting digestive enzyme distribution and activity.
Pathways
Syncollin plays a role in exocytosis and related signaling pathways. It interacts with proteins such as Rab3D which regulates vesicle docking and fusion. It is also implicated in pathways involving synaptotagmin which controls vesicular membrane fusion dynamics. Syncollin’s involvement in these pathways highlights its role in coordinating the timing and specificity of enzyme secretion which is essential for maintaining digestive processes in response to physiological cues.
Dysfunction in Syncollin correlates with pancreatitis where impaired secretory activity contributes to inflammation. Additionally Syncollin has potential connections to cystic fibrosis where aberrant secretory processes affect tissue health. The interaction of Syncollin with proteins like CFTR a cystic fibrosis transmembrane conductance regulator might influence the progression of these conditions suggesting possible targets for therapeutic intervention. Understanding the role of Syncollin in these disorders provides insights for developing strategies to manage pancreatic dysfunction.