Abcam, ab178684, Anti-GSTM1/2/4/5 antibody [EPR13338]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GSTM1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13338,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GSTM1 GSTM2 GSTM4 and GSTM5 proteins belong to the glutathione S-transferase family also known as GST mu class. These proteins play a role in detoxification by catalyzing the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Each GSTM isoform weighs roughly 25-28 kDa. They are expressed in various tissues most abundantly in the liver kidney and lungs.
Biological function summary
The glutathione S-transferase mu proteins protect cells from oxidative stress. They participate in the detoxification of reactive oxygen species and xenobiotics. These proteins often function as part of the larger enzyme complex that incorporates glutathione. Their activity impacts cellular survival by managing toxic substances that accumulate.
Pathways
GSTM proteins fit into important processes such as the xenobiotic metabolism pathway and the glutathione metabolism pathway. They work closely with other enzyme families like GST pi and GST alpha in the conjugation phase of detoxification. The interaction with proteins like cytochrome P450 responsible for the initial oxidation of toxins is also notable.
Alterations in GSTM proteins associate with conditions like cancer and asthma. For instance GSTM1 null variants often link to an increased risk of lung cancer because of impaired detoxification. Additionally these proteins connect with inflammation-related proteins in asthma influencing disease progression and response to treatment.