Abcam, ab178693, Anti-IRBIT antibody [EPR13409]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal IRBIT antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13409,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IRBIT also known as Inositol 145-Trisphosphate Receptor Binding Protein plays significant role in intracellular signaling. It interacts with the inositol 145-trisphosphate receptor (IP3R) to modulate calcium release from the endoplasmic reticulum. The protein has a molecular mass of approximately 54 kDa. IRBIT is expressed in a variety of tissues including the brain pancreas and heart highlighting its broad functional relevance in different physiological systems.
Biological function summary
IRBIT regulates diverse cellular processes influencing calcium signaling pathways and cell cycle progression. It acts as a regulatory subunit and forms a complex with IP3R modulating calcium influx based on cellular demands. Additionally IRBIT associates with other proteins such as the sodium bicarbonate cotransporter NBCe1-B facilitating ion transport and pH regulation which are essential for maintaining cellular homeostasis.
Pathways
IRBIT's role is essential in maintaining calcium balance and signal transduction. It participates in the calcium signaling pathway where its interaction with IP3R proves important for accurate calcium release and uptake. Moreover it is implicated in the bicarbonate transport pathway through its association with NBCe1-B linking to the regulation of ion transport and pH balance in cells processes critical for maintaining cellular function and communication.
An imbalance in IRBIT function associates with certain pathological conditions such as cystic fibrosis and cancer. In cystic fibrosis improper regulation of bicarbonate transport partly due to IRBIT affects mucus function. Additionally in cancer disruptions in calcium signaling pathways involving IRBIT can promote tumorigenesis. Pathway interactions with proteins like IP3R and NBCe1-B illustrate its significant contributions to disease mechanisms.