Abcam, ab179438, Anti-Thyroid Hormone Receptor alpha antibody [EPR7862]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal THA antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7862,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Thyroid Hormone Receptor alpha (THRA) also known as NR1A1 or c-erbA-1 acts as a nuclear receptor that binds thyroid hormones particularly triiodothyronine (T3). THRA weighs approximately 54 kDa. This receptor exists in various isoforms with the alpha-1 version playing a significant role in mediating thyroid hormone action. THRA is widely expressed in many tissues with high levels in the heart skeletal muscles and brain emphasizing its diverse functional impact.
Biological function summary
The receptor influences many cellular processes such as metabolism differentiation and development. It often works within a complex composed of other nuclear receptors and coregulators to regulate gene expression upon thyroid hormone binding. By altering transcriptional activity THRA affects cell growth energy metabolism and the proper functioning of vital organs. This regulation is critical during both developmental phases and adult physiological maintenance.
Pathways
THRA integrates within the thyroid hormone signaling and metabolic regulation pathways. It modulates genes involved in energy metabolism such as uncoupling proteins influencing how cells utilize and store energy. THRA interacts with related proteins like Thyroid Hormone Receptor beta (THRB) collectively orchestrating the intricate control of metabolic processes particularly in response to hormonal signals that adjust body functions based on physiological needs.
Mutations or dysfunction of THRA associates with conditions like RTHalpha (Resistance to Thyroid Hormone alpha) and some metabolic syndromes. RTHalpha manifests with symptoms such as impaired growth and cognitive deficits. THRA's interaction with THRB can exacerbate these issues highlighting their linked contribution to thyroid hormone resistance. Investigating these interactions presents opportunities for understanding and potentially treating related disorders more effectively.