Abcam, ab179956, Recombinant Human STK40 protein

Size: 20µg
Recombinant Human STK40 protein is a Human Full Length protein, in the 1 to 435 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, WB.
Key facts
Purity:>95% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:GST tag N-Terminus,
Applications:WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8N2I9,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STK40 also known as Serine/Threonine Kinase 40 or protein-cancelled testis is an important kinase involved in several cellular processes. This protein has a mass of approximately 52 kDa. STK40 is mainly expressed in embryonic tissues and adult testis but also observed in many other tissues highlighting its various roles during development and in adult organisms. STK40 functions by phosphorylating target proteins which affects their function and regulates their activities within the cell.
Biological function summary
STK40 influences cell differentiation and development. It forms part of signaling complexes interacting with various other proteins to impart its effect. STK40 influences pluripotency in stem cells by modulating transcription factors and signaling pathways critical for maintaining a stable differentiation state. Moreover STK40 is shown to play a role in adipogenesis by affecting pathways that control fat cell formation and distribution.
Pathways
STK40 functions actively within several signaling cascades notably the MAPK and Wnt pathways. In the MAPK pathway it coordinates with proteins like MAP3K7 to control transcriptional activation linked to cellular stress responses and differentiation processes. In the Wnt signaling pathway STK40 influences the stabilization of beta-catenin a central protein in regulating gene expression related to cell proliferation and fate decisions.
STK40 has connections to cancer and metabolic syndromes. Dysregulation of STK40 expression or function can lead to improper cell differentiation and proliferation contributing to tumorigenesis particularly in testicular cancer. In metabolic disorders such as obesity STK40’s role in adipogenesis can affect fat deposition and might interlink with other proteins like PPARγ which further influences lipid metabolism and insulin sensitivity. Understanding STK40’s role in these conditions highlights its potential as a therapeutic target.