Abcam, ab180128, Anti-LSM10 antibody [EPR13843]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal LSM10 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13843,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LSM10 also known as Sm-like protein LSm10 is a component of the LSm protein family with an approximate molecular mass of 10 kDa. This protein is ubiquitously expressed in various tissues playing a role predominantly in the nucleus. LSM10 is involved in the assembly and functioning of ribonucleoproteins related to its role in RNA processing and regulation.
Biological function summary
The role of LSM10 engages in RNA splicing and modification processes as part of a small nuclear ribonucleoprotein (snRNP) complex. Within the complex LSM10 contributes to the stability and assembly of snRNP particles facilitating the proper maturation of RNA molecules. LSM10's presence is critical for the formation of U7 snRNP which specifically addresses histone pre-mRNA processing and ensures efficient recycling and turnover of RNA.
Pathways
The protein functions prominently in RNA splicing pathways and histone RNA processing. LSM10 interacts with factors like LSM11 and other related proteins that assist in stabilizing RNA structures necessary for accurate gene regulation. The protein plays an integral role in connective pathways that facilitate histone mRNA transcription regulation and turnover involving partners such as the U7 snRNP complex and other splicing factors.
LSM10 exhibits links to conditions like spinal muscular atrophy and certain cancers. Alterations in the LSM10-related pathway might impact snRNP assembly influencing the molecular mechanisms behind these diseases. The protein connects to SMN1 known for its involvement in snRNP complex stability a factor critical in spinal muscular atrophy. Moreover aberrations in LSM10 activity or expression might contribute to cancer pathogenesis through disrupted RNA processing and gene expression regulation.