Abcam, ab180139, Anti-ITIH4 antibody [EPR11233(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ITIH4 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11233(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ITIH4 also known as inter-alpha-trypsin inhibitor heavy chain H4 is a serum protein with a molecular mass of approximately 120 kDa. It belongs to the inter-alpha-trypsin inhibitor (ITI) family. This protein is predominantly expressed in the liver and circulates in the blood. ITIH4 operates mechanically by binding to hyaluronic acid giving it a protective capability in the stabilization of the extracellular matrix.
Biological function summary
ITIH4 contributes to the inflammatory response and tissue repair processes. It forms part of a protease inhibitor complex known as ITI comprised of heavy and light chains that interact together. This complex acts in protecting tissues from damage by inhibiting serine proteases. Additionally ITIH4 has adaptive roles in modulating the inflammatory response facilitating tissue restoration and engaging in immune cell regulation.
Pathways
ITIH4 associates with inflammation and extracellular matrix organization pathways. Inflammation-related pathways involve interactions with several cytokines and matrix metalloproteinases contributing to the regulation of inflammatory responses. Within these pathways ITIH4 exhibits connection with proteins such as interleukin 6 (IL-6) playing roles in inflammation and tissue communication.
ITIH4 has been implicated in liver diseases and certain cancers. Its altered expression and functionality have associations with liver fibrosis where it may influence the extracellular matrix dynamics and hepatocellular carcinoma potentially impacting tumor microenvironments. ITIH4's connections to liver disease also relate it to alpha-1 antitrypsin which plays a part in liver protection and disease modulation.