Abcam, ab180147, Anti-CPVL antibody [EPR13153]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CPVL antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13153,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CPVL stands for Carboxypeptidase Vitellogenic-Like and it functions as a serine carboxypeptidase involved in protein degradation processes. Also known by the name serine carboxypeptidase vitellogenic-like CPVL has a molecular mass of approximately 54 kDa. It is expressed mainly in macrophages and monocytes which are important components in the body's immune system. The enzyme plays a role in breaking down cellular proteins as part of normal cellular maintenance and defense mechanisms.
Biological function summary
CPVL contributes to the catabolism of proteins within immune cells aiding in the removal of peptides generated from cellular turnover and antigen processing. As part of the larger molecular complex of proteasomes and other proteolytic systems it participates in maintaining intracellular protein homeostasis. CPVL's activity supports the immune response by processing phosphoproteins and contributing to antigen presentation therefore influencing immune surveillance and response to pathogens.
Pathways
CPVL functions in key biological routes such as protein degradation and immune system regulation processes. Within these pathways CPVL interacts with other peptidases and proteolytic enzymes including the ubiquitin-proteasome system. This interaction highlights its role in managing protein quality control and influencing processes related to inflammation pathways. CPVL might work alongside other proteases like cathepsin L in these pathways emphasizing their coordinated roles in protein catabolism.
CPVL has connections to inflammatory diseases such as atherosclerosis and certain autoimmune conditions. Abnormal expression or mutation of CPVL could lead to altered macrophage function contributing to these conditions' pathogenesis. The protein also interacts in disease contexts with factors like interleukin-6 a cytokine implicated in inflammatory responses. These links suggest CPVL's importance in understanding inflammatory disease mechanisms and potential therapeutic strategies.