Abcam, ab180174, Anti-SEMA3D antibody [EPR13458(B)] - C-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SEMA3D antibody. C-terminal. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13458(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SEMA3D also known as Semaphorin 3D is a member of the semaphorin protein family. It has a mass of approximately 87 kDa. SEMA3D acts as a signaling protein that plays a role in guiding neuronal and non-neuronal cell processes. It functions by binding to neuropilin and plexin receptors to regulate cell movement and positioning. Expression of SEMA3D occurs in various tissues with significant presence in the nervous system lungs and kidneys.
Biological function summary
SEMA3D influences axonal guidance angiogenesis and immune response. It participates as part of a complex with its receptors regulating signaling pathways that are important for nervous system development and vascular patterning. By altering cellular processes SEMA3D can impact how cells grow connect and interact within their environment affecting tissue morphogenesis and repair.
Pathways
SEMA3D interacts with the semaphorin signaling pathway and the VEGF (vascular endothelial growth factor) pathway. These pathways are essential for processes such as axon guidance and blood vessel formation. SEMA3D works closely with proteins like Plexin-A1 and Neuropilin-1 orchestrating cellular responses necessary for vascular and neural network development.
SEMA3D has connections to cancer progression and pulmonary diseases. Altered expression of SEMA3D can influence tumor growth and metastasis with changes in related proteins such as Neuropilin-1 affecting these processes. In pulmonary disorders SEMA3D expression levels can impact lung development and function linking to conditions like pulmonary fibrosis where the dysregulation of this protein and its receptor Plexin-A1 might play a role.