Abcam, ab180184, Anti-MLF2 antibody [EPR10245(2)] - C-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MLF2 antibody. C-terminal. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10245(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MLF2 also known as Myeloid Leukemia Factor 2 is a protein with an approximate mass of 35 kDa. It shows expression mainly in the nucleus and cytoplasm of cells. MLF2 takes part in the regulation of various cellular processes especially those involving cell growth and differentiation. Understanding its activity and expression pattern can help in dissecting its role in cellular function and disease.
Biological function summary
MLF2 contributes to cells' response to stress making it significant in maintaining cellular homeostasis. MLF2 can interact with other proteins to form complexes that regulate transcriptional processes. This regulation is important for normal cellular function and indicates that MLF2 has an influence on gene expression modulation impacting how the cell responds to different stimuli.
Pathways
MLF2 engages in the JAK/STAT signaling pathway which is important in processes like cell proliferation differentiation and apoptosis. It also interacts with the NF-kB signaling pathway important for immune response and inflammation regulation. Through these pathways MLF2 shares connections with proteins such as STAT3 and NF-kB indicating its integration into a network that maintains cellular activity and integrity.
MLF2 associates with cancer and myelodysplastic syndromes. Its altered expression or dysfunction can contribute to tumorigenesis due to its role in cell proliferation and differentiation pathways. In these disease contexts MLF2's interaction with proteins like JAK2 becomes critical as disruptions in these interactions may exacerbate disease progression. Understanding these connections helps in considering MLF2 as a potential therapeutic target in disease treatment strategies.