Abcam, ab180217, Anti-HOXA6 antibody - N-terminal

Size: 200µL
Goat Polyclonal HOXA6 antibody. N-terminal. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HOXA6 aa 1-50.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HOXA6 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P31267,
Specificity:ab180217 is expected to recognize isoform 1 (NP_004494.1) only.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab180217 ia purified from serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXA6 also known as Homeobox protein Hox-A6 is a transcription factor belonging to the homeobox family with a molecular mass of approximately 26 kDa. This protein plays an important role in regulating gene expression morphogenesis and cellular differentiation. HOXA6 is primarily expressed in embryonic tissues especially during early developmental stages. It is also detected in certain adult tissues though at lower levels. The protein contributes to the formation of body plans during embryonic development by controlling the transcription of other genes.
Biological function summary
HOXA6 is involved in numerous critical developmental processes. As a part of the Hox gene complex it helps establish the anterior-posterior axis which is essential for proper body patterning and segmentation. This protein affects the specialization of cells and tissues contributing to the formation of organs. Moreover it plays a role in cell growth differentiation and apoptosis influencing diverse developmental pathways.
Pathways
HOXA6 integrates into pathways that shape embryonic development and organogenesis. It has a significant involvement in the Wnt signaling pathway which regulates cell fate decisions proliferation and migration. HOXA6 cooperates with proteins such as β-catenin a central player in the Wnt pathway. Additionally it interacts within the retinoic acid signaling pathway which affects the differentiation of various cell types and guides developmental trajectories.
Aberrant expression or mutation of the HOXA6 gene associates with cancer and developmental disorders. In particular gastric cancer shows a correlation with misregulated HOXA6 expression implicating its role in tumorigenesis. This ties HOXA6 to other proteins like MYC and BCL2 which are involved in cancer progression. Furthermore congenital malformations specifically limb abnormalities may arise from Hox gene dysregulation highlighting the importance of precise HOXA6 expression during development.