Abcam, ab180850, Anti-RNF214 antibody [EPR12940]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RNF214 antibody. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12940,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RNF214 also known as Ring Finger Protein 214 is an E3 ubiquitin-protein ligase. It plays a role in tagging proteins with ubiquitin for regulated protein degradation. The protein has a mass of approximately 74 kDa. RNF214 shows expression in many tissues including prostate brain and ovary. This wide expression pattern implies a diverse function potential in cellular processes.
Biological function summary
RNF214 participates in protein homeostasis by facilitating the ubiquitination process. It functions as part of an E3 ligase complex which delivers ubiquitin molecules to substrate proteins. This modification signals these proteins for degradation by the proteasome. Through this activity RNF214 influences protein turnover and maintains cell homeostasis by removing damaged or misfolded proteins ensuring functional protein networks.
Pathways
RNF214 is involved in the ubiquitin-proteasome system and the regulation of MAPK signaling pathways. The protein works closely with other ubiquitin ligases to control protein levels impacting cellular responses like cell cycle and growth. In the MAPK signaling pathway RNF214 can modulate the stability of signaling molecules like MAPK which impacts cell proliferation and differentiation.
RNF214 has associations with neurodegenerative diseases and cancer. Aberrant functioning of RNF214 could lead to an accumulation of misfolded proteins contributing to neurodegenerative conditions like Alzheimer's disease. In cancer changes in RNF214 activity might disrupt normal cell cycle control leading to tumorigenesis. It often connects with other proteins like p53 in the context of these diseases highlighting the importance of its regulatory role in cellular homeostasis.