Abcam, ab180860, Anti-IRX1 antibody [EPR13139]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal IRX1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13139,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IRX1 also known as Iroquois homeobox 1 functions mechanically as a transcription factor. With a mass of approximately 51 kDa this protein plays an essential role in regulating gene expression during embryonic development. IRX1 expresses mainly in the heart central nervous system and various tissues involved in early development. The regulation and expression patterns make it an interesting target for developmental biology studies.
Biological function summary
IRX1 regulates tissue-specific gene expression and contributes to the establishment of body plans. As part of the Iroquois homeobox gene family it often functions in concert with other members to form a transcriptional complex. This complex is important for the proper development of several organs and systems including heart and brain structures. Its role in the morphogenesis of these tissues highlights its significance in developmental processes.
Pathways
IRX1 integrates into key developmental signaling pathways such as the Wnt signaling and Hedgehog pathways. These pathways are essential for cellular proliferation differentiation and patterning. IRX1 interacts with proteins like GLI1 and β-catenin which are pivotal within these pathways to modulate transcription of target genes. Its involvement supports neurodevelopmental and cardiac developmental processes.
IRX1 displays associations with certain congenital heart defects and oncological conditions including gastric cancer. Studies show that IRX1 dysregulation may lead to malformations in cardiac development linking it to heart defects. Additionally IRX1 interacts with factors like E2F1 in cancer pathways to influence tumor progression suggesting a potential role in tumorigenesis. Understanding these connections could facilitate the development of therapeutic interventions for conditions involving IRX1.