Abcam, ab181024, Anti-TID1 antibody [EPR12414]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TID1 antibody. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12414,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TID1 also known as Tumorous Imaginal Disc 1 or Tid1 functions as a mitochondrial DnaJ homolog characterized by its cochaperone activity. TID1 assists in protein folding and degradation processes within the cell by interacting with heat shock proteins such as Hsp70. The protein has a molecular mass of approximately 43 kDa. TID1 is mainly expressed in the mitochondria of various tissues including the heart skeletal muscles and brain.
Biological function summary
TID1 participates in maintaining mitochondrial integrity and cellular homeostasis. It is part of a complex involving multiple proteins that mediate signal transduction and apoptosis regulation. TID1 supports the correct folding and assembly of proteins imported into mitochondria directly impacting mitochondrial function. Additionally TID1 interacts with key molecules involved in apoptotic pathways influencing cell survival outcomes.
Pathways
TID1 plays roles in apoptosis and mitochondrial import pathways. Within the apoptosis pathway TID1 interacts with proteins like Bax and Bcl-2 influencing the release of cytochrome c. This release triggers the apoptosome formation activating the caspase cascade leading to programmed cell death. In mitochondrial import pathways TID1 aids the entry and proper folding of nuclear-encoded proteins into the mitochondrial matrix highlighting its connection to these essential cellular processes.
Dysfunction in TID1 relates to cancer and neurodegenerative diseases. Mutations or altered expressions of TID1 can disrupt apoptosis leading to the unchecked cell proliferation seen in cancers. In neurodegenerative contexts TID1's role in mitochondrial function links it to conditions like Huntington's disease where mitochondrial dysfunction is evident. In these disorders TID1’s interaction with apoptosis-related proteins like Bax becomes important in understanding disease progression and potential therapeutic targets.