Abcam, ab181028, Anti-NADK2 antibody [EPR13170]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NADK2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13170,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NADK2 also known as NAD kinase 2 is an enzyme that specifically phosphorylates nicotinamide adenine dinucleotide (NAD) to produce NADP using ATP as a phosphate donor. It has a molecular weight of approximately 32 kDa. Expression of NADK2 occurs in the mitochondria of various tissues including liver and muscle highlighting its importance in cellular metabolism where high-energy demand persists.
Biological function summary
The enzyme plays an important role in the production of NADP which is important for anabolic reactions and redox balance. It is not part of a larger protein complex but operates independently to maintain cellular NADP levels. NADK2 supports processes like fatty acid synthesis and oxidative stress response highlighting its diverse biological roles beyond energy metabolism.
Pathways
NADK2 significantly contributes to the oxidative phosphorylation and the pentose phosphate pathway. The enzyme acts alongside other proteins like glucose-6-phosphate dehydrogenase which also operates in NADP production and redox reactions. Together they form an integral part of pathways that are fundamental for cellular growth and repair by providing reducing power in the form of NADPH.
NADK2 exhibits connections to metabolic disorders such as non-alcoholic fatty liver disease. The enzyme's dysfunction can impair mitochondrial function contributing to the etiology of the disease. Additionally altered NADK2 activity relates to congenital diseases involving metabolic deficiencies where it exhibits interactions with mitochondrial proteins like ATP synthase impacting energy production and metabolic flexibility.