Abcam, ab181043, Anti-ARH antibody [EPR13115] - N-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ARH antibody. N-terminal. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13115,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ARH protein also known as autosomal recessive hypercholesterolemia protein plays an important role in the intracellular trafficking and endocytosis of low-density lipoprotein receptors (LDLR). ARH has a molecular mass of approximately 308 amino acids and is expressed primarily in the liver heart and adrenal gland. Its function is important in maintaining cholesterol homeostasis and influencing lipid metabolism by mediating receptor-ligand interactions.
Biological function summary
ARH facilitates the internalization of LDL particles by forming a complex with LDL receptors at the cell surface. This process helps in the uptake of cholesterol-rich lipoproteins an essential task for cell function. By binding adaptor proteins and clathrin ARH aids in creating pits that vesicles need during LDL endocytosis ensuring specific retrieval of receptors and ligands. This protein plays a role in maintaining cellular lipid balance and contributes to cholesterol regulation.
Pathways
ARH acts in the lipoprotein metabolism and cholesterol transport pathways by collaborating with other proteins. It interacts with LDLR and integrates into the clathrin-mediated endocytic pathway pivotal for cholesterol uptake and distribution within the body. It is associated with proteins such as LDLR and clathrin which perform key steps in lipoprotein processing and cholesterol homeostasis.
Alterations in ARH can lead to hypercholesterolemia a disorder characterized by elevated cholesterol levels in the blood and increased cardiovascular risk. ARH is associated with familial hypercholesterolemia reflecting its central role in cholesterol regulation. The protein's interaction with LDLR is important in this context as defects in this interaction result in impaired clearance of LDL from the bloodstream. Such disruptions emphasize the importance of ARH in lipid-related disorders and potential therapeutic targeting.