Abcam, ab181138, Anti-SLU7 antibody [EPR11111]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SLU7 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11111,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLU7 also known as Splicing Factor SLU7 is an essential component of the pre-mRNA splicing process. Weighing approximately 65 kDa SLU7 is mainly found in the nucleus of cells where splicing occurs. It plays an important role in the second catalytic step of alternative splicing by ensuring accurate 3' splice site selection. SLU7 assists in proper intron removal and exon joining during mRNA processing ensuring the production of mature mRNA. Expression of SLU7 is observed in various tissues but high levels are noted in the brain and liver.
Biological function summary
SLU7 influences the regulation of gene expression by participating in mRNA splicing. As part of the larger spliceosome complex SLU7 helps with the recognition of splice sites addressing both simple and more complex pre-mRNA structures. Its function impacts various cellular processes by modulating the diversity of protein products through alternative splicing. This diversity is important for cells to adapt to developmental cues and environmental changes impacting cell differentiation and the response to stress.
Pathways
SLU7 functions significantly in mRNA processing and RNA transport pathways. It interacts with other splicing factors such as U2AF35 and U2AF65 forming a network important for the precise removal of introns from pre-mRNA. SLU7's involvement in these pathways affects numerous cellular transcription-related processes and connects with gene regulatory networks influencing the broader system of gene expression.
Errors in SLU7 function have links to neurodegenerative diseases and certain cancers. In neurodegenerative conditions such as Alzheimer's disease altered splicing patterns due to SLU7 malfunction may contribute to the pathology. In cancer aberrant expression or mutations in SLU7 could disrupt normal splicing affecting cellular growth and tumor progression. Connections are seen with RBM17 and other spliceosomal proteins where deregulation can exacerbate disease development and progression.