Abcam, ab181162, Anti-TTC27 antibody [EPR13653]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TTC27 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13653,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TTC27 also known as Tetratricopeptide Repeat Protein 27 is a protein characterized by its tetratricopeptide repeat (TPR) domains. The molecular mass of TTC27 is approximately 143 kDa. It is expressed in various tissues with particularly high levels in the brain liver and testes. These TPR domains suggest that TTC27 may be involved in protein-protein interactions functioning as a scaffold for the assembly of multiprotein complexes.
Biological function summary
TTC27 plays important roles in cellular processes. It functions as a part of larger multiprotein complexes which indicates its role in maintaining cellular homeostasis and possibly influencing signaling pathways. The protein's distribution in the brain suggests its involvement in neurological functions though detailed mechanisms remain under investigation. TTC27's interaction with other proteins points towards its potential role in regulating cellular signaling and response.
Pathways
TTC27's involvement in specific signaling pathways highlights its importance in cellular communication. Recent studies have linked TTC27 to the MAPK/ERK pathway a critical pathway for cell proliferation and differentiation. It interacts with proteins such as MEK and ERK facilitating the transmission of extracellular signals to the nucleus. Additionally TTC27 may participate in the NOD-like receptor signaling pathway further influencing immune responses and inflammation processes.
TTC27's function and expression profile suggest potential links to certain conditions. Research indicates a connection between TTC27 and certain cancers where alterations in signaling pathways like MAPK/ERK could contribute to tumorigenesis. The correlation with proteins like ERK involved in cell cycle regulation highlights its role in cancer development. Furthermore TTC27's significant expression in the brain suggests possible involvement in neurological disorders drawing interest in its relationship with proteins implicated in neurodegenerative diseases.