Abcam, ab181194, Anti-TTC4 antibody [EPR13381]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TTC4 antibody. Suitable for IP, WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13381,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TTC4 also known as Tetratricopeptide Repeat Protein 4 has a molecular mass of approximately 44 kDa. It functions as a molecular chaperone assisting in the folding and stability of other proteins. TTC4 contains tetratricopeptide repeat (TPR) motifs which play a role in protein-protein interactions. These motifs enable TTC4 to interact with various cellular proteins. It is expressed widely in human tissues with higher levels observed in the heart brain and testis.
Biological function summary
The tetratricopeptide repeats in TTC4 facilitate its role as a part of multiprotein complexes. This protein takes part in regulating important cellular processes like cell cycle control and stress response. TTC4 assists in stabilizing proteins during cellular stress ensuring proper cellular function under adverse conditions. It may also interact with heat shock proteins (HSPs) contributing to protein homeostasis in cells.
Pathways
This protein is involved in important cellular processes including the signal transduction pathways and protein quality control pathways. TTC4 is notably involved in the chaperone-mediated autophagy pathway where it regulates the turnover and recycling of damaged proteins. It relates to proteins such as Hsp70 which are central to cellular stress response mechanisms. This relationship plays an important role in maintaining protein stability and cellular function.
TTC4's role in maintaining cellular protein stability links it to conditions caused by protein misfolding. Misregulation in its function may contribute to neurodegenerative diseases such as Alzheimer's disease where excessive protein aggregation occurs. Additionally TTC4 interacts with proteins like Tau which are important in the pathogenesis of Alzheimer's. Aberrations in TTC4 might also influence cancer progression due to its involvement in cell cycle regulation linking it to proteins such as p53 known for its tumor suppressor role.