Abcam, ab181212, Anti-PREB antibody [EPR13252]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PREB antibody. Suitable for IP, WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13252,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PREB also known as prolactin regulatory element-binding protein weighs approximately 41 kDa. It acts as a transcription factor that binds to specific DNA sequences to regulate gene expression. Researchers find it expressed in various tissues including the pituitary gland liver and pancreas. Its activity involves the control of prolactin transcription a hormone important for lactation and possibly other genes with related promoter elements.
Biological function summary
PREB regulates gene expression by interacting with mitogenic signaling pathways. As part of a protein complex it influences cellular proliferation and secretion processes. Its transcriptional regulation mechanism allows cells to respond to physiological changes both at developmental stages and in adult organisms. This regulation plays a role in maintaining normal cellular functions indicating its importance in various biological processes.
Pathways
PREB impacts the MAPK/ERK signaling pathway and the pancreatic secretion pathway. These pathways are significant for cellular growth differentiation and secretion. Furthermore PREB interacts with proteins like prolactin and ERK contributing to the regulation of transcriptional responses necessary for effective signal processing. These interactions highlight the involvement of PREB in essential physiological and cellular processes.
PREB relates to conditions such as breast cancer and type 2 diabetes. Its dysregulation has been associated with abnormal cell proliferation seen in breast cancer where it may interact with proteins like estrogen receptor. Furthermore PREB influences insulin regulation in the pancreas linking it to type 2 diabetes. By modulating gene expression it directly or indirectly contributes to the progression or prevention of these disorders.